{"id":11378,"date":"2022-03-01T09:26:36","date_gmt":"2022-03-01T08:26:36","guid":{"rendered":"https:\/\/www.ummto.dz\/fs\/?p=11378"},"modified":"2022-03-02T08:19:46","modified_gmt":"2022-03-02T07:19:46","slug":"avis-de-soutenance-de-these-doctorat-de-mme-ouldlamara-kamilia","status":"publish","type":"post","link":"https:\/\/www.ummto.dz\/fs\/avis-de-soutenance-de-these-doctorat-de-mme-ouldlamara-kamilia\/","title":{"rendered":"Avis de Soutenance de Doctorat en Chimie de Mme Ould lamara-Hechiche Kamilia."},"content":{"rendered":"\n[et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb4.14.8″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″][et_pb_row _builder_version=\u00a0\u00bb4.14.8″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.14.8″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.14.8″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]

Mme<\/sup> OULD LAMARA-HECHICHE Kamilia<\/span><\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Soutiendra sa th\u00e8se de Doctorat 3\u00e9me<\/sup>Cycle LMD en Chimie Pharmaceutique.<\/strong><\/p>\n

Intitul\u00e9:\u00a0\u00ab<\/strong> Synth\u00e8se et \u00e9valuation biologique de s\u00e9ries de compos\u00e9s h\u00e9t\u00e9rocycliques<\/span>.<\/strong> \u00bb<\/p>\n

<\/strong><\/p>\n

\u00a0<\/strong>Le\u00a0: 03 Mars 2022 <\/span><\/strong>\u00e0 la salle de visioconf\u00e9rences du Centre des Syst\u00e8mes et R\u00e9seaux de l\u2019Universit\u00e9\u00a0<\/span> Mouloud Mammeri de Tizi-Ouzou \u00e0 10h :00<\/span>.<\/strong><\/span><\/p>\n

Directrice de Th\u00e8se\u00a0: Pr CHEBLI-MAKHLOUFI Malika<\/strong><\/span><\/p>\n

Devant le jury d\u2019examen suivant<\/u><\/strong>\u00a0:<\/u><\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n
Mme<\/sup>. MAZARI-HACHI Tassadit<\/strong><\/span><\/td>\nProfesseure<\/strong><\/span><\/td>\nUMMTO<\/strong><\/span><\/td>\nPr\u00e9sidente<\/strong><\/span><\/td>\n<\/tr>\n
Mme<\/sup>. CHEBLI-MAKHLOUFI Malika<\/strong><\/span><\/td>\nProfesseure<\/strong><\/span><\/td>\nUMMTO<\/strong><\/span><\/td>\nRapporteur<\/strong><\/span><\/td>\n<\/tr>\n
M. BEHR Jean-Bernard<\/strong><\/span><\/td>\nProfesseur<\/strong><\/span><\/td>\nUniversit\u00e9 de Reims, France<\/strong><\/span><\/td>\nCo-Rapporteur<\/strong><\/span><\/td>\n<\/tr>\n
Mme<\/sup>. OUKACHA-HIKEM Djamila<\/strong><\/span><\/td>\nMCA<\/strong><\/span><\/td>\nUMMTO<\/strong><\/span><\/td>\nExaminatrice<\/strong><\/span><\/td>\n<\/tr>\n
Mme<\/sup>. AMAR Anissa<\/strong><\/span><\/td>\nMCA<\/strong><\/span><\/td>\nUMMTO<\/strong><\/span><\/td>\nExaminatrice<\/strong><\/span><\/td>\n<\/tr>\n
Mme<\/sup>. ABDI Yamina<\/strong><\/span><\/td>\nMCA<\/strong><\/span><\/td>\n(ENST), Alger<\/strong><\/span><\/strong><\/span><\/td>\nExaminatrice<\/strong><\/span><\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

R\u00e9sum\u00e9<\/strong><\/span><\/p>\n

La synth\u00e8se de nouvelles mol\u00e9cules organiques h\u00e9t\u00e9rocycliques susceptibles de pr\u00e9senter une ou plusieurs activit\u00e9s biologiques, en ayant recours \u00e0 des m\u00e9thodes simples et efficaces est d\u2019une importance capitale pour la compr\u00e9hension de ph\u00e9nom\u00e8nes biologiques de toutes sortes. Cette th\u00e8se est focalis\u00e9e dans un premier temps sur l\u2019\u00e9tude de la s\u00e9lectivit\u00e9 de la r\u00e9action des d\u00e9riv\u00e9s du salicylald\u00e9hyde vis-\u00e0-vis la 4-hydroxycoumarine dans diff\u00e9rentes conditions. Deux s\u00e9ries de compos\u00e9s h\u00e9t\u00e9rocycliques ont \u00e9t\u00e9 isol\u00e9es et un des produits obtenus montre une excellente activit\u00e9 antioxydante \u00e0 de tr\u00e8s faibles concentrations. Un compos\u00e9 de chaque s\u00e9rie a \u00e9t\u00e9 soumis au docking mol\u00e9culaire et \u00e0 une \u00e9tude de la dynamique mol\u00e9culaire dans le cadre de la recherche de nouvelles mol\u00e9cules stables inhibitrices de la prot\u00e9ine Kinase activ\u00e9e par les mitog\u00e8nes P38.<\/span><\/p>\n

Dans un deuxi\u00e8me volet, la synth\u00e8se des c\u00e9tones \u03b1,\u03b2-insatur\u00e9es associ\u00e9es \u00e0 un noyau pyridinyle et \u00e0 un aryle diversement substitu\u00e9 en utilisant la r\u00e9action classique de Claisen-Schmidt ou la condensation de Knoevenagel a \u00e9t\u00e9 notre deuxi\u00e8me objectif. Ces c\u00e9tones \u03b1, \u03b2-insatur\u00e9es pr\u00e9sentant une tr\u00e8s bonne activit\u00e9 antimicrobienne sont utilis\u00e9es comme mati\u00e8res premi\u00e8res pour la synth\u00e8se de nouvelles chalcone-oximes. Les r\u00e9sultats de l\u2019activit\u00e9 antioxydante in-vitro<\/em> de ces derni\u00e8res sont nettement meilleures que leurs pr\u00e9curseurs. Les r\u00e9sultats du docking mol\u00e9culaire et de la dynamique mol\u00e9culaire r\u00e9alis\u00e9s sur les chalcone-oximes obtenues montrent que ces compos\u00e9s peuvent agir de mani\u00e8re tr\u00e8s int\u00e9ressante comme inhibiteurs potentiels de l’ac\u00e9tylcholinest\u00e9rase (fep-mAChE).<\/span><\/p>\n

Mots cl\u00e9s<\/strong> :<\/span><\/p>\n

H\u00e9t\u00e9rocycle, Coumarine, Chalcone, Oximes, Activit\u00e9 antioxydante, Activit\u00e9 antimicrobienne, Docking mol\u00e9culaire, Dynamique mol\u00e9culaire, Prot\u00e9ine MAPK P38, Inhibiteurs de l’ac\u00e9tylcholinest\u00e9rase, Prot\u00e9ine fep-mAChE.<\/span><\/p>\n

 <\/p>\n

Abstract<\/strong><\/span><\/p>\n

The synthesis of new heterocyclic organic molecules capable of exhibiting one or more biological activities, using simple and efficient methods, is of paramount importance for the understanding of biological phenomena of all kinds. This thesis is focused initially on the study of the selectivity of the reaction of salicylaldehyde derivatives vis-\u00e0-vis 4-hydroxycoumarin under different conditions. Two series of heterocyclic compounds were isolated and one of the products obtained shows excellent antioxidant activity at very low concentrations. A compound of each series was subjected to molecular docking and a study of molecular dynamics in the context of the search for new stable molecules inhibiting the protein Kinase activated by the P38 mitogens.<\/span><\/p>\n

In a second part, the synthesis of \u03b1, \u03b2-unsaturated ketones associated with a pyridinyl ring and a variously substituted aryl using the classic Claisen-Schmidt reaction or the Knoevenagel condensation was our second objective. These \u03b1, \u03b2-unsaturated ketones exhibiting very good antimicrobial activity are used as raw materials for the synthesis of new chalcone-oximes. The results of the in-vitro<\/em> antioxidant activity of the latter are significantly better than their precursors. The results of molecular docking and molecular dynamics carried out on the chalcone-oximes obtained show that these compounds can act in a very interesting way as potential inhibitors of acetylcholinesterase (fep-mAChE).<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Keywords<\/strong>: <\/span><\/p>\n

Heterocycle, Coumarin, Chalcone, Oximes, Antioxidant activity, Antimicrobial activity, Molecular docking, Molecular dynamics, MAPK P38 protein, Acetylcholinesterase inhibitors, fep-mAChE protein.<\/span><\/p>\n

<\/strong><\/span><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

Mme OULD LAMARA-HECHICHE Kamilia \u00a0 Soutiendra sa th\u00e8se de Doctorat 3\u00e9meCycle LMD en Chimie Pharmaceutique. Intitul\u00e9:\u00a0\u00ab Synth\u00e8se et \u00e9valuation biologique de s\u00e9ries de compos\u00e9s h\u00e9t\u00e9rocycliques. \u00bb \u00a0Le\u00a0: 03 Mars 2022 \u00e0 la salle de visioconf\u00e9rences du Centre des Syst\u00e8mes et R\u00e9seaux de l\u2019Universit\u00e9\u00a0 Mouloud Mammeri de Tizi-Ouzou \u00e0 10h :00. Directrice de Th\u00e8se\u00a0: Pr CHEBLI-MAKHLOUFI […]<\/p>\n","protected":false},"author":13,"featured_media":132,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-11378","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe"],"yoast_head":"\nAvis de Soutenance de Doctorat en Chimie de Mme Ould lamara-Hechiche Kamilia. - Facult\u00e9 des Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ummto.dz\/fs\/avis-de-soutenance-de-these-doctorat-de-mme-ouldlamara-kamilia\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Avis de Soutenance de Doctorat en Chimie de Mme Ould lamara-Hechiche Kamilia. - Facult\u00e9 des Sciences\" \/>\n<meta property=\"og:description\" content=\"Mme OULD LAMARA-HECHICHE Kamilia \u00a0 Soutiendra sa th\u00e8se de Doctorat 3\u00e9meCycle LMD en Chimie Pharmaceutique. 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