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La candidate Madame Sabrina HALIT <\/span><\/strong>soutiendra sa th\u00e8se de Doctorat 3\u00e8me cycle LMD en Chimie,\u00a0 <\/strong>sp\u00e9cialit\u00e9: Chimie des Mat\u00e9riaux et de l’Environnement, <\/strong>le 08 f\u00e9vrier 2023 <\/strong><\/span>\u00e0 10h<\/strong>.<\/span><\/p>\n Lieu\u00a0: Salle de soutenance de la Facult\u00e9 des Sciences<\/p>\n Intitul\u00e9\u00a0de la th\u00e8se\u00a0:<\/p>\n Conception, synth\u00e8se et \u00e9valuation biologique de compos\u00e9s h\u00e9t\u00e9rocycliques azot\u00e9s et oxyg\u00e9n\u00e9s<\/strong><\/span><\/p>\n Devant le jury d\u2019examen compos\u00e9 de\u00a0:<\/p>\n <\/strong><\/p>\n Le public est cordialement invit\u00e9<\/strong><\/p>\n R\u00e9f\u00a0: D\u00e9cision de soutenance N\u00b001\/VRPGRS\/2023<\/strong><\/span><\/p>\n <\/strong><\/p>\n [\/et_pb_accordion_item][et_pb_accordion_item title=\u00a0\u00bbR\u00e9sum\u00e9 de la th\u00e8se en Fran\u00e7ais\u00a0\u00bb open_toggle_text_color=\u00a0\u00bb#E02B20″ _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb body_text_color=\u00a0\u00bb#000000″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb open=\u00a0\u00bboff\u00a0\u00bb]<\/p>\n Cette th\u00e8se se concentre dans sa premi\u00e8re partie, sur la synth\u00e8se d’une s\u00e9rie de d\u00e9riv\u00e9s de la benzylpyrazolylcoumarine, impliquant la r\u00e9action multicomposants de la 4-hydroxycoumarine, d’ac\u00e9toac\u00e9tate d’\u00e9thyle, d’hydrazine hydrate et d’ald\u00e9hydes, en utilisant \u00a0le dod\u00e9cylbenz\u00e8nesulfonate de sodium (DBSS) comme catalyseur. Les propri\u00e9t\u00e9s antifongiques et antioxydantes des compos\u00e9s synth\u00e9tis\u00e9s ont \u00e9galement \u00e9t\u00e9 \u00e9valu\u00e9es et les r\u00e9sultats \u00e9taient prometteurs. Les \u00e9tudes de docking ont montr\u00e9 qu’un produit de la s\u00e9rie synth\u00e9tis\u00e9e a une forte affinit\u00e9 pour la prot\u00e9ine N-myristoyltransf\u00e9rase (NMT) et se lie au site actif de la prot\u00e9ine de la m\u00eame mani\u00e8re que les inhibiteurs utilis\u00e9s en m\u00e9decine et pourrait faire partie de nouvelles classes d’agents antifongiques cliniquement efficaces. Visant \u00e0 synth\u00e9tiser des produits hautement fonctionnels, la synth\u00e8se d\u2019une nouvelle s\u00e9rie de mol\u00e9cules d\u00e9riv\u00e9es d’isonicotinoylpyrazolylcoumarine par la strat\u00e9gie d’hybridation mol\u00e9culaire \u00e0 partir des d\u00e9riv\u00e9s de la 3-ac\u00e9toac\u00e9tylcoumarine avec l’isoniazide a \u00e9t\u00e9 r\u00e9alis\u00e9e dans un second temps. Les compos\u00e9s obtenus ont \u00e9t\u00e9 \u00e9valu\u00e9s pour leurs activit\u00e9s antifongiques et deux produits ont montr\u00e9 des activit\u00e9s inhibitrices potentiellement \u00e9lev\u00e9es. Les r\u00e9sultats de l’activit\u00e9 antioxydante \u00e9taient \u00e9galement satisfaisants. Les \u00e9tudes relations structure-activit\u00e9 ont d\u00e9montr\u00e9 que la pr\u00e9sence de groupes nitro et hydroxyle dans le cycle aromatique des cycles coumarine et pyrazoline conf\u00e9rait une activit\u00e9 antioxydante et antifongique accrue. En outre, des \u00e9tudes de docking mol\u00e9culaire ont \u00e9t\u00e9 r\u00e9alis\u00e9es pour le compos\u00e9 pr\u00e9sentant une bonne activit\u00e9 antifongique afin d’\u00e9valuer son potentiel en tant qu’inhibiteur de la prot\u00e9ine fongique (Phytase A) d’Aspergillus niger <\/em>et les r\u00e9sultats sugg\u00e8rent que notre isonicotinoylpyrazolylcoumarine peut agir comme un agent antifongique prometteur.<\/p>\n Mots cl\u00e9s\u00a0: <\/strong>H\u00e9t\u00e9rocycle, Coumarine, Dod\u00e9cylbenz\u00e8nesulfonate de sodium (DBSS), Benzylpyrazolylcoumarine, R\u00e9action multicomposants, Hydrazide d’acide isonicotinique, Pyrazoline, Activit\u00e9 antioxydante, Activit\u00e9 antifongique, Docking mol\u00e9culaire, prot\u00e9ine N-myristoyltransf\u00e9rase (NMT), prot\u00e9ine fongique (Phytase A) d’Aspergillus.<\/p>\n [\/et_pb_accordion_item][et_pb_accordion_item title=\u00a0\u00bbR\u00e9sum\u00e9 de la th\u00e8se en Anglais\u00a0\u00bb open=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb body_text_color=\u00a0\u00bb#000000″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n Abstract<\/strong><\/p>\n This thesis focuses in its first part, on the synthesis of a series of benzylpyrazolylcoumarin derivatives, involving the multicomponent reaction of 4-hydroxycoumarin, ethyl acetoacetate, hydrazine hydrate and benzaldehyde derivatives, using sodium dodecylbenzenesulfonate (SDBS) as catalyst. The antifungal and antioxidant properties of the synthesized compounds were also evaluated and the results were promising. Docking studies showed that one product of the synthesized series has a high affinity for the protein N-myristoyltransferase (NMT) and binds to the active site of the protein in the same way as inhibitors used in medicine and could be part of new classes of clinically effective antifungal agents. Aiming to synthesize highly functional products, the synthesis of a new series of isonicotinoylpyrazolylcoumarin-derived molecules by the molecular hybridization strategy from 3-acetoacetylcoumarin derivatives with isoniazid was performed in a second step. The obtained compounds were evaluated for their antifungal activities and two products showed potentially high inhibitory activities. The results of the antioxidant activity were also satisfactory. Structure-activity relationship studies demonstrated that the presence of nitro and hydroxyl groups in the aromatic ring of the coumarin and pyrazoline rings conferred enhanced antioxidant and antifungal activity. In addition, molecular docking studies were performed for the compound with good antifungal activity to evaluate its potential as an inhibitor of the fungal protein (Phytase A) from Aspergillus niger<\/em> and the results suggest that our isonicotinoylpyrazolylcoumarin may act as a promising antifungal agent.<\/p>\n \n Keywords: <\/strong>Heterocycle, Coumarin, Sodium dodecylbenzenesulfonate (SDBS), Benzylpyrazolylcoumarin, Multicomponent reaction, Isonicotinic acid hydrazide, Pyrazoline, Antioxidant activity, Antifungal activity, Molecular docking, Protein N-myristoyltransferase (NMT), Fungal protein (Phytase A) from Aspergillus.<\/em><\/p>\n [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" La candidate Madame Sabrina HALIT soutiendra sa th\u00e8se de Doctorat 3\u00e8me cycle LMD en Chimie,\u00a0 sp\u00e9cialit\u00e9: Chimie des Mat\u00e9riaux et de l’Environnement, le 08 f\u00e9vrier 2023 \u00e0 10h. Lieu\u00a0: Salle de soutenance de la Facult\u00e9 des Sciences Intitul\u00e9\u00a0de la th\u00e8se\u00a0: Conception, synth\u00e8se et \u00e9valuation biologique de compos\u00e9s h\u00e9t\u00e9rocycliques azot\u00e9s et oxyg\u00e9n\u00e9s Devant le jury d\u2019examen […]<\/p>\n","protected":false},"author":13,"featured_media":14680,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1,10],"tags":[],"class_list":["post-17649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe","category-new_dep_chimie"],"yoast_head":"\n\n\n
\n Mme. Leila DERMECHE<\/strong><\/td>\n Prof.<\/td>\n UMMTO<\/td>\n Pr\u00e9sidente<\/td>\n<\/tr>\n \n Mme. <\/strong>Malika MAKHLOUFI-CHEBLI<\/strong><\/td>\n Prof.<\/td>\n UMMTO<\/td>\n Rapporteur<\/td>\n<\/tr>\n \n Mme. Amina BENAZZOUZ-TOUAMI<\/strong><\/td>\n MCA<\/td>\n UMMTO<\/td>\n Co- Rapporteur<\/td>\n<\/tr>\n \n Mme. <\/strong>Yamina AIT ABDESSELAM-ABDI<\/strong><\/td>\n MCA<\/td>\n ENST, Alger<\/td>\n Examinatrice<\/td>\n<\/tr>\n \n Mme. <\/strong>Ouarda HOCINE-BENLOUNES<\/strong><\/td>\n MCA<\/td>\n UMMTO<\/td>\n Examinatrice<\/td>\n<\/tr>\n \n Mr. <\/strong>Mohamed Ali BENMENSOUR<\/strong><\/td>\n MCA<\/td>\n UMMTO<\/td>\n Examinateur<\/td>\n<\/tr>\n \n Mme. Souhila BOUAZIZ-TERRACHET<\/strong><\/td>\n Prof.<\/td>\n UMBB<\/td>\n Invit\u00e9e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n